发明授权
US07786144B2 Sulphur containing pyrazole derivatives as selective cannabinoid CB1 receptor antagonists
有权
含硫吡唑衍生物作为选择性大麻素CB1受体拮抗剂
- 专利标题： Sulphur containing pyrazole derivatives as selective cannabinoid CB1 receptor antagonists
- 专利标题（中）： 含硫吡唑衍生物作为选择性大麻素CB1受体拮抗剂
-
申请号： US11754544申请日： 2007-05-29
-
公开(公告)号： US07786144B2公开(公告)日： 2010-08-31
- 发明人: Josephus H. M. Lange , Cornelis G. Kruse , Bernard J. Van Vliet
- 申请人： Josephus H. M. Lange , Cornelis G. Kruse , Bernard J. Van Vliet
- 申请人地址： NL Weesp
- 专利权人： Solvay Pharmaceuticals B.V.
- 当前专利权人： Solvay Pharmaceuticals B.V.
- 当前专利权人地址： NL Weesp
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- 主分类号： A61K31/4155
- IPC分类号： A61K31/4155 ; A61K31/4453 ; C07D231/10 ; C07D403/12
摘要：
The present invention relates to sulphur containing pyrazole derivatives, and their S-oxidized active metabolites, as selective cannabinoid CB1 receptor antagonists having a high CB1/CB2 receptor subtype selectivity, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of these pyrazole derivatives, to pharmaceutical compositions comprising one or more of these pyrazole derivatives as active ingredients, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders. The compounds have the general formula (I) wherein the symbols have the meanings given in the specification.
公开/授权文献
信息查询
IPC分类:
