发明授权
US07759377B2 Acylaminothiazole derivatives and use thereof as beta-amyloid inhibitors
失效
酰氨基噻唑衍生物及其作为β-淀粉样蛋白抑制剂的用途
- 专利标题: Acylaminothiazole derivatives and use thereof as beta-amyloid inhibitors
- 专利标题(中): 酰氨基噻唑衍生物及其作为β-淀粉样蛋白抑制剂的用途
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申请号: US12051924申请日: 2008-03-20
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公开(公告)号: US07759377B2公开(公告)日: 2010-07-20
- 发明人: Sylvie Baltzer , Marc Pascal , Viviane Van Dorsselaer
- 申请人: Sylvie Baltzer , Marc Pascal , Viviane Van Dorsselaer
- 申请人地址: FR Paris
- 专利权人: Sanofi-Aventis
- 当前专利权人: Sanofi-Aventis
- 当前专利权人地址: FR Paris
- 代理商 Balaram Gupta
- 优先权: FR0400388 20040116; FR0408116 20040722
- 主分类号: A61K31/426
- IPC分类号: A61K31/426 ; C07D277/38
摘要:
Compounds of formula (I) as defined herein: inhibit the formation of the β-amyloid peptide (β-A4) and are, therefore, useful in the treatment of pathologies in which a β-amyloid peptide (β-A4) formation inhibitor provides a therapeutic benefit. Particular such pathologies are senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy, cerebrovascular disorders, frontotemporal dementias and Pick's disease, post-traumatic dementias, pathologies linked to neuroinflammatory processes, Huntington's disease and Korsakov's syndrome.
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