An in vivo imaging device may include a capsule shaped housing and an image sensor. The capsule shaped housing may have a longitudinal axis and a window. The image sensor (e.g., a CMOS sensor) may include a pixel array portion and a circuitry portion. The circuitry portion may be segregated, for example longitudinally, from the pixel array portion. The pixel array portion may be disposed within said housing substantially parallel to said longitudinal axis.A light deflecting element disposed at an angle smaller than 45 degrees with respect to the pixel array portion introduces image distortion which is compensated by a distortion compensation mechanism.