Invention Grant
- Patent Title: Process for preparing halogenoalkylnitrates
- Patent Title (中): 卤代烷基硝酸盐的制备方法
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Application No.: US11667970Application Date: 2005-11-09
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Publication No.: US07745496B2Publication Date: 2010-06-29
- Inventor: Romano Rivolta , Peter Finlander
- Applicant: Romano Rivolta , Peter Finlander
- Applicant Address: FR Valbonne
- Assignee: Nicox S.A.
- Current Assignee: Nicox S.A.
- Current Assignee Address: FR Valbonne
- Agency: Arent Fox LLP
- Priority: EP04292785 20041125
- International Application: PCT/EP2005/055865 WO 20051109
- International Announcement: WO2006/056535 WO 20060601
- Main IPC: A61K31/02
- IPC: A61K31/02 ; C07C291/02
Abstract:
A process for preparing a compound of formula (I) X-(CH2)n-ONO2 (I) wherein: X is a halogen atom selected from Cl, Br, I; n is an integer from 3 to 6; said process comprising the slow addition of a compound of formula (II) X-(CH2)n-OH (II) wherein X and n are as defined above to a nitrating agent selected from the group consisting of concentrated nitric acid/concentrated sulfuric acid (sulfonitric mixture), nitric acid alone, NaNO2 in trifluoroacetic acid, nitronium salts such as NO2BF4 and an organic solvent selected from the group consisting of CH2Cl2, CHCl3, CCl4, perfluorohexane, perfluoroheptane. The invention refers also to solutions containing: a compound of general formula (I) and a solvent selected from the group consisting of CH2Cl2, CHCl3, CCl4, perfluorohexane, perfluoroheptane, characterized in that the compound of formula (I) is present in a concentration not higher than 20% by weight.
Public/Granted literature
- US20080004463A1 Process For Preparing Halogenoalkylnitrates Public/Granted day:2008-01-03
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