发明授权
US07732458B2 Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal composition containing them
失效
脱氢山梨醇，脱氢卡泊肽或其组合物的制备方法，其用途和含有它们的药物组合物
- 专利标题： Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal composition containing them
- 专利标题（中）： 脱氢山梨醇，脱氢卡泊肽或其组合物的制备方法，其用途和含有它们的药物组合物
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申请号： US11806874申请日： 2007-06-05
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公开(公告)号： US07732458B2公开(公告)日： 2010-06-08
- 发明人: Weidong Zhang , Hanxiong Li , Huiliang Li , Chuan Zhang , Runhui Liu , Juan Su , Xike Xu
- 申请人： Weidong Zhang , Hanxiong Li , Huiliang Li , Chuan Zhang , Runhui Liu , Juan Su , Xike Xu
- 申请人地址： CN Guangzhou
- 专利权人： Hanxiong Li
- 当前专利权人： Hanxiong Li
- 当前专利权人地址： CN Guangzhou
- 代理机构： IPFortune LLC
- 代理商 Ruay L. Ho
- 优先权： CN200410099269 20041229
- 主分类号： A61K31/4738
- IPC分类号： A61K31/4738 ; C07D491/02
摘要：
A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.
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