Invention Grant
- Patent Title: Implantable device comprising phosphorus-containing macrolides
- Patent Title (中): 含有磷的大环内酯类植入装置
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Application No.: US11650017Application Date: 2007-01-05
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Publication No.: US07709020B2Publication Date: 2010-05-04
- Inventor: David L. Berstein , Leonard W. Rozamus , Yihan Wang , Chester A. Metcalf, III
- Applicant: David L. Berstein , Leonard W. Rozamus , Yihan Wang , Chester A. Metcalf, III
- Applicant Address: US MA Cambridge
- Assignee: ARIAD Pharmaceuticals, Inc.
- Current Assignee: ARIAD Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agent David L. Berstein
- Main IPC: A61K31/675
- IPC: A61K31/675 ; A61F2/00

Abstract:
This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which:A is absent or is —O—, —S— or —NR2—;Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)x; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M′ moiety may be saturated or unsaturated; each occurrence of x is independently an integer from 1-6; and the other variables are as defined herein.
Public/Granted literature
- US20070190106A1 Phosphorus-containing compounds & uses thereof Public/Granted day:2007-08-16
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