发明授权
US07691976B2 BRAF35 protein and BRCA2/BRAF35 complex and methods of use
失效
BRAF35蛋白和BRCA2 / BRAF35复合物及其使用方法
- 专利标题： BRAF35 protein and BRCA2/BRAF35 complex and methods of use
- 专利标题（中）： BRAF35蛋白和BRCA2 / BRAF35复合物及其使用方法
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申请号： US10416387申请日： 2001-11-13
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公开(公告)号： US07691976B2公开(公告)日： 2010-04-06
- 发明人: Ramin Shiekhattar
- 申请人： Ramin Shiekhattar
- 申请人地址： US PA Philadelphia
- 专利权人： The Wistar Institute
- 当前专利权人： The Wistar Institute
- 当前专利权人地址： US PA Philadelphia
- 代理机构： Licata & Tyrrell P.C.
- 国际申请： PCT/US01/47101 WO 20011113
- 国际公布： WO02/38795 WO 20020516
- 主分类号： C07K14/00
- IPC分类号： C07K14/00 ; C07K17/00 ; A61K38/16 ; G01N33/00 ; G01N1/00 ; G01N1/18
摘要：
An isolated nucleic acid sequence of BRAF35 and polypeptides encoded thereby are provided, as well as a multiprotein complex, and an antibody capable of binding selectively to the BRAF35 protein. Related agents and compositions which modulate interaction between BRCA2 and BRAF35 and methods of their use for screening for the BRCA2 protein, suppressing tumors and identifying DNA damage in cells indicative of a risk for developing cancer are also provided.
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