发明授权
- 专利标题： Pyridothienopyridazinone derivatives as mGluR1 antagonists
- 专利标题（中）： 吡啶并噻吩并哒嗪酮衍生物作为mGluR1拮抗剂
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申请号： US11505140申请日： 2006-08-16
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公开(公告)号： US07687501B2公开(公告)日： 2010-03-30
- 发明人: Chad E. Bennett , William J. Greenlee , Chad E. Knutson , Duane A. Burnett
- 申请人： Chad E. Bennett , William J. Greenlee , Chad E. Knutson , Duane A. Burnett
- 申请人地址： US NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： US NJ Kenilworth
- 代理商 Krishna G. Bannerjee; Kenrick L. Vidale; Keith D. MacMillan
- 主分类号： C07D495/14
- IPC分类号： C07D495/14 ; C07D417/14 ; A61K31/4985 ; C07D213/85 ; C07D495/04 ; C07D239/30 ; C07D239/58 ; A61P25/06 ; A61P25/04 ; A61P25/22 ; A61P25/28
摘要：
In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J3, X, Z, and R1, R3, and R4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.
公开/授权文献
- US20070072864A1 Fused tricyclic mGIuR1 antagonists as therapeutic agents 公开/授权日：2007-03-29
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