发明授权
- 专利标题： Palladium-catalyzed coupling of aryl halides with alkynes
- 专利标题（中）： 钯催化的芳基卤化物与炔烃的偶联
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申请号： US11364878申请日： 2006-02-28
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公开(公告)号： US07642391B1公开(公告)日： 2010-01-05
- 发明人: Sameer Urgaonkar , John G. Verkade
- 申请人： Sameer Urgaonkar , John G. Verkade
- 申请人地址： US IA Ames
- 专利权人： Iowa State University Research Foundation, Inc.
- 当前专利权人： Iowa State University Research Foundation, Inc.
- 当前专利权人地址： US IA Ames
- 代理机构： Schwegman, Lundberg, & Woessner, P.A.
- 代理商 Michael H. Haukaas
- 主分类号： C07C1/26
- IPC分类号： C07C1/26
摘要：
A method is provided to couple an aryl halide to an alkyne comprising reacting a compound of the formula ArX, wherein Ar is a substituted or unsubstituted aryl group and X is I or Br, with a compound of the formula HC≡C—R1 wherein R1 is a substituted or unsubstituted organic group, in the presence of an effective amount of a phosphine-free, oxime-free palladium catalyst; (C1-C4)alkyl N+(−OAc) or an alkali metal carbonate, to yield a compound of the formula Ar—C≡C—R1, wherein the reaction is carried out in the absence of an organic amine or copper(I).
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