Disclosed is a method and a device for security-inspection of liquid articles with radiations, which relate to the field of radiation inspection technology. The method comprises steps of acquiring original environment information, emitting radiation beams to transmit the liquid articles, receiving the radiation beams transmitted through the liquid articles to form multi-angle projection data, computing a radiation absorption coefficient of the liquid articles to be detected by inverse operation of the multi-angle projection data, based on the initial environmental information and the uniformity of the liquid articles, and comparing the radiation absorption coefficients with the preset data to get the relevant information of the liquid articles. Comparing with the prior art, the present invention is not subjected to affection of cuter package of the liquid article, and is advantageous of high anti-jamming high accuracy, high safety and reliability, low cost and small size.