发明授权
US07553854B2 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling
有权
6-O-取代的苯并恶唑和苯并噻唑化合物以及抑制CSF-1R信号传导的方法
- 专利标题: 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling
- 专利标题(中): 6-O-取代的苯并恶唑和苯并噻唑化合物以及抑制CSF-1R信号传导的方法
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申请号: US11737069申请日: 2007-04-18
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公开(公告)号: US07553854B2公开(公告)日: 2009-06-30
- 发明人: James C Sutton , Marion Wiesmann , Weibo Wang , Mika Lindvall , Jiong Lan , Savithri Ramurthy , Anu Sharma , Elizabeth J. Mieuli , Liana M. Klivansky , William Lenahan , Susan Kaufman , Hong Yang , Simon C. Ng , Keith Pfister , Allan S. Wagman , Victoria Sung , Martin Sendzik
- 申请人: James C Sutton , Marion Wiesmann , Weibo Wang , Mika Lindvall , Jiong Lan , Savithri Ramurthy , Anu Sharma , Elizabeth J. Mieuli , Liana M. Klivansky , William Lenahan , Susan Kaufman , Hong Yang , Simon C. Ng , Keith Pfister , Allan S. Wagman , Victoria Sung , Martin Sendzik
- 申请人地址: US CA Emeryville
- 专利权人: Novartis Vaccines and Diagnostics, Inc.
- 当前专利权人: Novartis Vaccines and Diagnostics, Inc.
- 当前专利权人地址: US CA Emeryville
- 代理商 Vinit Kathardekar; Hugo Eng
- 主分类号: C07D215/00
- IPC分类号: C07D215/00 ; A61K31/44
摘要:
Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.
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