发明授权
US07425532B2 Use of alanyl aminopeptidase inhibitors and pharmaceutical compositions containing said inhibitors
失效
丙氨酰氨基肽酶抑制剂和含有所述抑制剂的药物组合物的用途
- 专利标题： Use of alanyl aminopeptidase inhibitors and pharmaceutical compositions containing said inhibitors
- 专利标题（中）： 丙氨酰氨基肽酶抑制剂和含有所述抑制剂的药物组合物的用途
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申请号： US10520014申请日： 2003-07-04
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公开(公告)号： US07425532B2公开(公告)日： 2008-09-16
- 发明人: Siegfried Ansorge , Janine Tadje , Uwe Lendeckel
- 申请人： Siegfried Ansorge , Janine Tadje , Uwe Lendeckel
- 申请人地址： DE Magdeburg
- 专利权人： IMTM GmbH
- 当前专利权人： IMTM GmbH
- 当前专利权人地址： DE Magdeburg
- 代理机构： Hodgson Russ LLP
- 优先权： DE10230381 20020705
- 国际申请： PCT/EP03/07199 WO 20030704
- 国际公布： WO2004/004750 WO 20040115
- 主分类号： A61K38/05
- IPC分类号： A61K38/05 ; A61K31/495
摘要：
The present invention relates to the use of one inhibitor or of several inhibitors of alanyl aminopeptidases and/or of enzymes having a similar substrate specificity for the induction of the production of TGF-β1 and of the expression of TGF-β1 in and/or on Treg cells and relates to the use for preventing and/or treating autoimmune diseases, allergies, arteriosclerosis and for suppressing graft rejection reactions. The invention furthermore relates to uses, wherein peptide fragments of pathogenic autoantigens or synthetic analogs and/or specific antigenic components of pathogenic microorganisms are used in addition.
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