发明授权
US07375123B2 1,2,4-thiadiazole derivatives as melanocortin receptor modulators
失效
作为黑皮质素受体调节剂的1,2,4-噻二唑衍生物
- 专利标题： 1,2,4-thiadiazole derivatives as melanocortin receptor modulators
- 专利标题（中）： 作为黑皮质素受体调节剂的1,2,4-噻二唑衍生物
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申请号： US11344772申请日： 2006-02-01
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公开(公告)号： US07375123B2公开(公告)日： 2008-05-20
- 发明人: Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
- 申请人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
- 申请人地址： US NJ Raritan
- 专利权人： Ortho-McNeil Pharmaceutical, Inc.
- 当前专利权人： Ortho-McNeil Pharmaceutical, Inc.
- 当前专利权人地址： US NJ Raritan
- 主分类号： A61K31/433
- IPC分类号： A61K31/433 ; C07D285/08
摘要：
The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
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