发明授权
- 专利标题: Constructs for delivery of therapeutic agents to neuronal cells
- 专利标题(中): 用于将治疗剂递送至神经元细胞的构建体
-
申请号: US10130973申请日: 2000-12-04
-
公开(公告)号: US07368532B2公开(公告)日: 2008-05-06
- 发明人: Clifford Charles Shone , John Mark Sutton , Nigel Silman
- 申请人: Clifford Charles Shone , John Mark Sutton , Nigel Silman
- 申请人地址: GB
- 专利权人: Syntaxin Limited
- 当前专利权人: Syntaxin Limited
- 当前专利权人地址: GB
- 代理机构: Sterne, Kessler, Goldstein & Fox P.L.L.C
- 优先权: GB9928530.6 19991202; GB0008658.7 20000407
- 国际申请: PCT/GB00/04644 WO 20001204
- 国际公布: WO01/58936 WO 20010816
- 主分类号: C07K1/00
- IPC分类号: C07K1/00 ; C07K14/10 ; C07K17/00 ; C07K14/00 ; C07K16/00
摘要:
A non-toxic polypeptide, for delivery of a therapeutic agent to a neuronal cell, comprises a binding domain that binds to the neuronal cell, and a translocation domain that translocates the therapeutic agent into the neuronal cell, wherein the translocation domain is not a HN domain of a clostridial toxin and is not a fragment or derivative of a HN domain of a clostridial toxin.
公开/授权文献
信息查询