发明授权
- 专利标题: Dibenzylamine compound and medicinal use thereof
- 专利标题(中): 二苄胺化合物及其药用
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申请号: US10503185申请日: 2003-08-29
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公开(公告)号: US07332514B2公开(公告)日: 2008-02-19
- 发明人: Kimiya Maeda , Hironobu Nagamori , Hiroshi Nakamura , Hisashi Shinkai , Yasunori Suzuki , Daisuke Takahashi , Toshio Taniguchi
- 申请人: Kimiya Maeda , Hironobu Nagamori , Hiroshi Nakamura , Hisashi Shinkai , Yasunori Suzuki , Daisuke Takahashi , Toshio Taniguchi
- 申请人地址: JP Tokyo
- 专利权人: Japan Tobacco Inc.
- 当前专利权人: Japan Tobacco Inc.
- 当前专利权人地址: JP Tokyo
- 代理机构: Leydig, Voit & Mayer, Ltd.
- 优先权: JP2002-255604 20020830; JP2003-107161 20030410
- 国际申请: PCT/JP03/11041 WO 20030829
- 国际公布: WO2004/020393 WO 20040311
- 主分类号: A61K31/42
- IPC分类号: A61K31/42 ; A61K31/41 ; C07D263/30 ; C07D257/04
摘要:
A dibenzylamine compound represented by the formula (1) wherein R1 and R2 are each a C1-6 alkyl group optionally substituted by halogen atoms and the like; R3, R4 and R5 are each a hydrogen atom, a halogen atom and the like, or R3 and R4 may form, together with carbon atoms bonded thereto, a homocyclic or heterocyclic ring optionally having substituent(s); A is —N(R7) (R8) and the like; ring B is an aryl group or a heterocyclic residue; R6 is a hydrogen atom, a halogen atom, a nitro group, a C1-6 alkyl group and the like; n is an integer of 1 to 3, a prodrug thereof and a pharmaceutically acceptable salt thereof show selective and potent CETP inhibitory activity, and therefore, they can be provided as therapeutic or prophylactic agents for hyperlipidemia or arteriosclerosis and the like.
公开/授权文献
- US20050059810A1 Dibenzylamine compound and medicinal use thereof 公开/授权日:2005-03-17
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