发明授权
- 专利标题： Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof
- 专利标题（中）： 哌嗪酰基哌啶衍生物，其制备和治疗用途
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申请号： US10516808申请日： 2003-06-05
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公开(公告)号： US07294628B2公开(公告)日： 2007-11-13
- 发明人: Françoise Bono , Michaël Bosch , Victor Dos Santos , Jean-Marc Herbert , Dino Nisato , Bernard Tonnerre , Jean Wagnon
- 申请人： Françoise Bono , Michaël Bosch , Victor Dos Santos , Jean-Marc Herbert , Dino Nisato , Bernard Tonnerre , Jean Wagnon
- 申请人地址： FR Paris
- 专利权人： Sanofi-Aventis
- 当前专利权人： Sanofi-Aventis
- 当前专利权人地址： FR Paris
- 代理商 Balaram Gupta
- 优先权： FR0207001 20020607
- 国际申请： PCT/FR03/01686 WO 20030605
- 国际公布： WO03/104226 WO 20031218
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; A61K31/4965 ; C07D241/04 ; C07D295/00
摘要：
The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) in which: n is 1 or 2; R1 represents a halogen atom; a trifluoromethyl radical; a (C1-C4) alkyl; a (C1-C4)alkoxy; a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom; a group —OR5; a group —CH2OR5; a group —NR6R7; a group —NR8COR9; a group —NR8CONR10R11; a group —CH2NR12R13; a group —CH2NR8CONR14R15; a (C1-C4)alkoxycarbonyl; a group —CONR16R17; or else R3 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; R4 represents the aromatic group 1,3-thiazol-2-yl of formula: Preparation process and therapeutic application.
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