Invention Grant
US07291764B1 Cloning pigs using non-quiescent differentiated donor cells or nuclei
有权
使用非静止分化供体细胞或细胞核克隆猪
- Patent Title: Cloning pigs using non-quiescent differentiated donor cells or nuclei
- Patent Title (中): 使用非静止分化供体细胞或细胞核克隆猪
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Application No.: US09394902Application Date: 1999-09-13
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Publication No.: US07291764B1Publication Date: 2007-11-06
- Inventor: Steven L. Stice , Jose Cibelli , James Robl , Paul Golueke
- Applicant: Steven L. Stice , Jose Cibelli , James Robl , Paul Golueke
- Applicant Address: US MA Amherst
- Assignee: University of Massachusetts, a Public Institution of Higher Education of the Commonwealth of Massachusetts, as Represented by its Amherst Campus, Office of Vice Chancellor for Research at Amherst
- Current Assignee: University of Massachusetts, a Public Institution of Higher Education of the Commonwealth of Massachusetts, as Represented by its Amherst Campus, Office of Vice Chancellor for Research at Amherst
- Current Assignee Address: US MA Amherst
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N5/00 ; A01K67/00
Abstract:
An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring. Production of genetically engineered or transgenic pig embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.
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