Invention Grant
US07279477B2 Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
有权
用作代谢调节剂的丙二酰辅酶A脱羧酶抑制剂
- Patent Title: Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
- Patent Title (中): 用作代谢调节剂的丙二酰辅酶A脱羧酶抑制剂
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Application No.: US10466926Application Date: 2002-01-22
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Publication No.: US07279477B2Publication Date: 2007-10-09
- Inventor: Thomas Arrhenius , Mi Chen , Jie Fei Cheng , Yujin Huang , Alex Michael Nadzan , Sovouthy Tith , David Mark Wallace , Bin Liu , Masahiro Nishimoto , Gary D. Lopaschuk , Jason R. Dyck
- Applicant: Thomas Arrhenius , Mi Chen , Jie Fei Cheng , Yujin Huang , Alex Michael Nadzan , Sovouthy Tith , David Mark Wallace , Bin Liu , Masahiro Nishimoto , Gary D. Lopaschuk , Jason R. Dyck
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- International Application: PCT/US02/02179 WO 20020122
- International Announcement: WO02/064136 WO 20020822
- Main IPC: A61K31/5375
- IPC: A61K31/5375 ; C07D265/30
Abstract:
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
Public/Granted literature
- US20040063671A1 Malonyl-coa decarboxylase inhibitors useful as metabolic modulators Public/Granted day:2004-04-01
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