发明授权
- 专利标题： Methods for treating or preventing angiogenesis-dependent symptoms
- 专利标题（中）： 治疗或预防血管生成依赖症状的方法
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申请号： US10536274申请日： 2003-12-02
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公开(公告)号： US07259149B2公开(公告)日： 2007-08-21
- 发明人: Kazuya Hiraoka , Seiji Yamamoto , Yasufumi Kaneda , Ryuichi Morishita , Toshio Ogihara
- 申请人： Kazuya Hiraoka , Seiji Yamamoto , Yasufumi Kaneda , Ryuichi Morishita , Toshio Ogihara
- 申请人地址： JP Osaka
- 专利权人： AnGes MG, Inc.
- 当前专利权人： AnGes MG, Inc.
- 当前专利权人地址： JP Osaka
- 代理机构： Townsend and Townsend and Crew LLP
- 国际申请： PCT/JP03/15400 WO 20031202
- 国际公布： WO2004/050126 WO 20040617
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12N15/63
摘要：
A method for enhancing the transfection efficiency of naked plasmid DNA in treating and/or preventing angiogenesis-dependent symptoms is provided by the present inventions. According to the present method, a suitable naked plasmid DNA is subjected for intramuscular injection under increased pressure inside the muscle or hyperbaric oxygen. Angiogenesis-dependent symptoms, including wounds, inflammatory diseases, critical limb ischemia, ischemia heart diseases, cerebral infarction, diabetic neuropathy, spinal canal stenosis, etc., may be treated by the present methods.
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