Invention Grant
US07195882B2 Monoclonal antibodies specific for buprenorphine and metabolites thereof
有权
对丁丙诺啡和其代谢物特异性的单克隆抗体
- Patent Title: Monoclonal antibodies specific for buprenorphine and metabolites thereof
- Patent Title (中): 对丁丙诺啡和其代谢物特异性的单克隆抗体
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Application No.: US10453256Application Date: 2003-06-03
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Publication No.: US07195882B2Publication Date: 2007-03-27
- Inventor: Richard T. Root , Mitali Ghoshal
- Applicant: Richard T. Root , Mitali Ghoshal
- Applicant Address: US IN Indianapolis
- Assignee: Roche Diagnostics Operations, Inc.
- Current Assignee: Roche Diagnostics Operations, Inc.
- Current Assignee Address: US IN Indianapolis
- Agency: Roche Diagnostics Operations, Inc.
- Agent Marilyn L. Amick
- Main IPC: C01N33/535
- IPC: C01N33/535 ; C01N33/533 ; C07K16/44 ; C07K17/06 ; C07D451/00
Abstract:
The present invention relates to monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof. The present invention further relates to buprenorphine metabolite conjugates for the production of monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof and hybridoma cells that produce the monoclonal antibodies. The invention also relates to immunoassay methods for determining buprenorphine and/or one or more buprenorphine metabolites in a sample using the novel antibodies and conjugates of the present invention.
Public/Granted literature
- US20040248222A1 Monoclonal antibodies specific for buprenorphine and metabolites thereof Public/Granted day:2004-12-09
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