Invention Grant
US07034152B2 Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
有权
制备抗病毒剂的方法[1S-（1α，3α，4beta）] - 2-氨基-1,9-二氢-9- [4-羟基-3-（羟甲基）-2-亚甲基环戊基] -6H-嘌呤 -6-one
![Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one](/docs/US/2006-04-25/US07034152B2/abs.jpg.600x600.jpg)
- Patent Title: Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
- Patent Title (中): 制备抗病毒剂的方法[1S-（1α，3α，4beta）] - 2-氨基-1,9-二氢-9- [4-羟基-3-（羟甲基）-2-亚甲基环戊基] -6H-嘌呤 -6-one
-
Application No.: US10734012Application Date: 2003-12-11
-
Publication No.: US07034152B2Publication Date: 2006-04-25
- Inventor: Yadagiri R. Pendri , Chung-Pin H. Chen , Sunil S. Patel , Jeffrey M. Evans , Jing Liang , David R. Kronenthal , Gerald L. Powers , Siva Josyula Prasad , Jeffrey T. Bien , Zhongping Shi , Ramesh N. Patel , Amit Banerjee , Yeung Yu Chan , Sushil K. Rijhwani , Ambarish K. Singh , Shaopeng Wang , Milan Stojanovic , David J. Kucera , Richard P. Polniaszek , Charles Lewis , John Thottathil , Dhileepkumar Krishnamurty , Maotang X. Zhou , Purushotham Vemishetti
- Applicant: Yadagiri R. Pendri , Chung-Pin H. Chen , Sunil S. Patel , Jeffrey M. Evans , Jing Liang , David R. Kronenthal , Gerald L. Powers , Siva Josyula Prasad , Jeffrey T. Bien , Zhongping Shi , Ramesh N. Patel , Amit Banerjee , Yeung Yu Chan , Sushil K. Rijhwani , Ambarish K. Singh , Shaopeng Wang , Milan Stojanovic , David J. Kucera , Richard P. Polniaszek , Charles Lewis , John Thottathil , Dhileepkumar Krishnamurty , Maotang X. Zhou , Purushotham Vemishetti
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Warren K. Volles
- Main IPC: C07D473/18
- IPC: C07D473/18 ; C07D7/08 ; C07D473/40 ; C07F7/10 ; C07F7/18
![Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one](/abs-image/US/2006/04/25/US07034152B2/abs.jpg.150x150.jpg)
Abstract:
Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
Public/Granted literature
Information query
