Invention Grant
- Patent Title: Th1 inducing natural adjuvant for heterologous antigens
- Patent Title (中): Th1诱导异源抗原的天然佐剂
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Application No.: US10222100Application Date: 2002-08-16
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Publication No.: US06936263B2Publication Date: 2005-08-30
- Inventor: Hilde Revets , Pierre Cornelis , Patrick De Baetselier
- Applicant: Hilde Revets , Pierre Cornelis , Patrick De Baetselier
- Applicant Address: BE Zwjjnaarde
- Assignee: Vlaams Interuniversitair Instituut voor Biotechnologie VZW
- Current Assignee: Vlaams Interuniversitair Instituut voor Biotechnologie VZW
- Current Assignee Address: BE Zwjjnaarde
- Agency: TraskBritt
- Priority: EP00200589 20000218
- Main IPC: A61K39/39
- IPC: A61K39/39 ; A61P37/04 ; C07K14/21 ; C07K14/44 ; C07K16/10 ; A61K39/00 ; A61K39/38 ; A61K39/385 ; A61K39/02 ; A61K39/108 ; A61K38/00 ; A61K9/127 ; C12N1/12 ; C12P1/00 ; C12P21/04
Abstract:
The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates specifically to the use of OprI—antigen fusion proteins to elicit the Type-1 response. More particularly, the present invention is directed to pharmaceutical formulations comprising OprI and/or OprI fusion proteins, optionally together with a suitable excipient, to stimulate the Th1 dependent, cellular immune response.
Public/Granted literature
- US20030059439A1 Th1 inducing natural adjuvant for heterologous antigens Public/Granted day:2003-03-27
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