Invention Grant
- Patent Title: Treatment of preeclampsia, toxemia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
- Patent Title (中): 联合孕激素和一氧化氮合酶底物和/或供体治疗先兆子痫，毒血症和早产
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Application No.: US09121849Application Date: 1998-07-24
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Publication No.: US06844320B1Publication Date: 2005-01-18
- Inventor: Robert E. Garfield , Krzysztof Chwalisz , Radoslaw Bukowski , Chandra Yallampalli
- Applicant: Robert E. Garfield , Krzysztof Chwalisz , Radoslaw Bukowski , Chandra Yallampalli
- Applicant Address: US TX Austin DE Berlin
- Assignee: Board of Regents, The University of Texas System,Schering Aktiengesellschaft
- Current Assignee: Board of Regents, The University of Texas System,Schering Aktiengesellschaft
- Current Assignee Address: US TX Austin DE Berlin
- Agency: Millen White Zelano & Branigan P.C.
- Main IPC: A61K31/04
- IPC: A61K31/04 ; A61K31/195 ; A61K31/198 ; A61K31/295 ; A61K31/341 ; A61K31/565 ; A61K31/57 ; A61K31/60 ; A61P13/02 ; A61P15/00 ; A61P15/06 ; A61K33/26 ; A61K31/21 ; A61K38/19
Abstract:
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclooxygenase inhibitor, a PGI2-mimetic, a thromboxane (TXA2) inhibitor, a compound possessing TXA2-agonistic and TXA2-inhibiting properties, a compound possessing TXA2-antagonistic and PGI2-memetic activities, and a TXA2 antagonist.
Information query
