A piezoelectric transformation driving apparatus for driving elements or products to be driven by a high or a low voltage includes a pulse-width modulation (PWM) control unit, a plurality of driving units, a plurality of transformation units, a plurality of piezoelectric units, and a plurality of loads. The PWM control unit outputs signals of the same phase and frequency to drive synchronously the driving units, the transformation units, the piezoelectric units and the loads to operate synchronously.