Use of 2-amino-thiazoline derivatives as inhibitors of inducible NO-synthase

Invention Grant

US06699867B2 Use of 2-amino-thiazoline derivatives as inhibitors of inducible NO-synthase 失效

Title translation: 使用2-氨基 - 噻唑啉衍生物作为诱导型NO合成酶的抑制剂

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Patent Title: Use of 2-amino-thiazoline derivatives as inhibitors of inducible NO-synthase
Patent Title (中): 使用2-氨基 - 噻唑啉衍生物作为诱导型NO合成酶的抑制剂
Application No.: US10291084

Application Date: 2002-11-08
Publication No.: US06699867B2

Publication Date: 2004-03-02
Inventor: Antony Bigot , Jean-Christophe Carry , Serge Mignani
Applicant: Antony Bigot , Jean-Christophe Carry , Serge Mignani
Priority: FR0114510 20011109
Main IPC: A61K31496
IPC: A61K31496

Use of 2-amino-thiazoline derivatives as inhibitors of inducible NO-synthase

Abstract:

The present invention relates to the use of 2-amino-thiazoline derivatives of formula (I): in which either Y is a methylene (CH2) and X is chosen from the following groups: O, NH, (C1-C4) N-Alkyl, N-Bn, N-Ph, N-(2-Py), N-(3-Py), N-(4-Py), N-2-pyrimidyl, N-5-pyrimidyl, S, SO, SO2, CH2 or CHPh; or Y is a carbonyl (C═O) and X is chosen from the following groups: NH, N-Ph, N-(2-Py), N-(3-Py), N-(4-Py), N-2-pyrimidyl or N-5-pyrimidyl or pharmaceutically acceptable salts thereof as inhibitors of inducible NO-synthase.

Abstract(Chinese):

本发明涉及式（I）的2-氨基 - 噻唑啉衍生物的用途：其中Y是亚甲基（CH 2），X选自下列基团：O，NH，（C 1 -C 4）烷基，N-Bn，N-Ph，N-（2-Py），N-（3-Py），N-（4-Py），N-2-嘧啶基，N-5-嘧啶基， SO2，CH2或CHPh; 或者Y是羰基（C = O），X选自下列基团：NH，N-Ph，N-（2-Py），N-（3-Py），N-（4-Py），N -2-嘧啶基或N-5-嘧啶基或其药学上可接受的盐作为诱导型NO合成酶的抑制剂。

Public/Granted literature

US20030166646A1 Use of 2-amino-thiazoline derivatives as inhibitors of inducible no-synthase Public/Granted day:2003-09-04

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