发明授权
- 专利标题: Preparation of cyclic lactams
- 专利标题(中): 制备环状内酰胺
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申请号: US10257877申请日: 2002-10-17
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公开(公告)号: US06683178B2公开(公告)日: 2004-01-27
- 发明人: Frank Ohlbach , Andreas Ansmann , Peter Bassler , Rolf-Hartmuth Fischer , Hermann Luyken , Stefan Maixner , Johann-Peter Melder
- 申请人: Frank Ohlbach , Andreas Ansmann , Peter Bassler , Rolf-Hartmuth Fischer , Hermann Luyken , Stefan Maixner , Johann-Peter Melder
- 优先权: DE10021201 20000503
- 主分类号: C07D20108
- IPC分类号: C07D20108
摘要:
The invention relates to a method for producing cyclic lactams of formula (II) by reacting a compound (I) of formula (I) with water in the presence of an organic, liquid dilution agent in the liquid phase. In formula (II), n and m respectively can have the values 0, 1, 2, 3, 4, 5, 6, 7, 8 and 9 and the sum of n+m is at least 3, preferably at least 4 and R1 and R2 represent C1-C6 alkyl, C5-C7 cycloalkyl or C6-C12 aryl groups. In formula (I), R1, R2, m and n are defined as above and R represents nitrile, carboxylic acid amide and carboxylic acid groups. The inventive method is characterized in that a) compound (I) is reacted with water in the liquid phase in the presence of an organic, liquid dilution agent (III) to form a mixture (IV) containing a lactam (II) and said mixture (IV) is subjected to an aqueous treatment to obtain a two-phase system.
公开/授权文献
- US20030114664A1 Method for producing cyclic lactams 公开/授权日:2003-06-19
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