Invention Grant
US06677329B1 Non-aromatic estrogenic steroids with a hydrocarbon substituent in position 11
失效
在11位具有烃取代基的非芳族雌激素类固醇
- Patent Title: Non-aromatic estrogenic steroids with a hydrocarbon substituent in position 11
- Patent Title (中): 在11位具有烃取代基的非芳族雌激素类固醇
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Application No.: US10070262Application Date: 2002-05-29
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Publication No.: US06677329B1Publication Date: 2004-01-13
- Inventor: Hubert Jan Jozef Loozen , Gerrit Herman Veeneman , Wilhelmus Gerardus Eduardus Joseph Schoonen
- Applicant: Hubert Jan Jozef Loozen , Gerrit Herman Veeneman , Wilhelmus Gerardus Eduardus Joseph Schoonen
- Priority: EP99202900 19990906
- Main IPC: A61K3156
- IPC: A61K3156
Abstract:
Disclosed are novel, selective estrogens type having a steroid skeleton with a non-aromatic A-ring and a free or capped hydroxyl group at carbon atom No. 3. The estrogens satisfy general formula (I), in which R1 is H, (C1-C3)alkyl or (C2-C3)acyl; R2 is H, &agr;-(C1-C4)alkyl, &agr;-(C2-C4)alkenyl or &agr;-(C2-C4)alkynyl; R3 is H or (C1-C4)alkyl, (C2-C4)alkenyl or (C2-C4)alkynyl, each at location 15 or 16 of the steroid skeleton; R4 is H or (C1-C5)alkyl, (C2-C5)alkenyl or (C2-C5)alkynyl, each optionally substituted with halogen; preferred is ethynyl; R5 is H, (C1-C3)alkyl or (C2-C3)acyl; R6 is (C1-C5)alkyl, (C2-C5)alkenyl, (C2-C5)alkynyl or (C1-C5)alkylidene, each optionally substituted.
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