Invention Grant
- Patent Title: Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates
- Patent Title (中): 碱性抗生素无机酸加成盐和草酸盐中间体的制备方法
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Application No.: US10030909Application Date: 2002-01-14
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Publication No.: US06642377B1Publication Date: 2003-11-04
- Inventor: Akio Kayano , Hiroyuki Chiba , Taiju Nakamura , Shin Sakurai , Hiroyuki Ishizuka , Hiroyuki Saito , Yuuki Komatsu , Manabu Sasho , Nobuaki Sato , Shigeto Negi
- Applicant: Akio Kayano , Hiroyuki Chiba , Taiju Nakamura , Shin Sakurai , Hiroyuki Ishizuka , Hiroyuki Saito , Yuuki Komatsu , Manabu Sasho , Nobuaki Sato , Shigeto Negi
- Priority: JP11-216806 19990730; JP11-216807 19990730
- Main IPC: C07D47720
- IPC: C07D47720
Abstract:
A production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid: wherein the ring A means the basic antibiotic; R10 means a protected functional group used in organic synthesis; Ak—E means the alkali earth metal; and B means the inorganic acid, respectively.
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