发明授权
- 专利标题: Quinoline and quinazoline compounds useful in therapy
- 专利标题(中): 喹啉和喹唑啉化合物可用于治疗
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申请号: US09812083申请日: 2001-03-19
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公开(公告)号: US06642242B2公开(公告)日: 2003-11-04
- 发明人: Alan John Collis , David Nathan Abraham Fox , Julie Newman
- 申请人: Alan John Collis , David Nathan Abraham Fox , Julie Newman
- 优先权: GB9526546 19951223
- 主分类号: A61K31517
- IPC分类号: A61K31517
摘要:
The invention provides compounds of formula (I), wherein R1 represents C1-4 alkoxy optionally substituted by one or more fluorine atoms; R2 represents H or C1-6 alkoxy optionally substituted by one or more fluorine atoms; R3 represents one or more groups independently selected from H, halogen, C1-4 alkoxy and CF3; in addition, R2 and one R3 group may together represent —OCH2—, the methylene group being attached to the ortho-position of the pendant phenyl ring; R4 represents a 4-, 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, O and S, the ring being optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, O and S, the ring system as a whole being optionally substituted; X represents CH or N; and L is absent or represents a cyclic group or an open chain group; and pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful in the treatment of inter alia benign prostatic hyperplasia.
公开/授权文献
- US20020049322A1 Quinoline and quinazoline compounds useful in therapy 公开/授权日:2002-04-25
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