This invention relates to a hollow fiber membrane module to be used in industrial fields such as the semiconductor industry, food processing industry, pharmaceutical industry, and medical industry, and to a method for the production thereof. Permselective hollow fiber membranes having rigidity are cheese-wound in a plurality of layers, thereby forming a hollow fiber membrane bundle. One terminal part of this hollow fiber membrane bundle together with a case is adhered and solidified with a thermally molten mass of thermoplastic resin, thereby forming a solidified part. This solidified part is cut to form a sealed part serving to open terminal parts of the hollow fiber membranes.