发明授权
US06620841B1 Aromatic heterocycle compounds having HIV integrase inhibiting activities
失效
具有HIV整合酶抑制活性的芳族杂环化合物
- 专利标题： Aromatic heterocycle compounds having HIV integrase inhibiting activities
- 专利标题（中）： 具有HIV整合酶抑制活性的芳族杂环化合物
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申请号： US09857632申请日： 2001-06-07
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公开(公告)号： US06620841B1公开(公告)日： 2003-09-16
- 发明人: Toshio Fujishita , Tomokazu Yoshinaga , Akihiko Sato
- 申请人： Toshio Fujishita , Tomokazu Yoshinaga , Akihiko Sato
- 优先权： JP10-371270 19981225; JP11-247479 19990901
- 主分类号： A61K3134
- IPC分类号： A61K3134
摘要：
A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COORA wherein RA is hydrogen or ester residue, —CONRBRC wherein RB and RC each is independently hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl; and A1 is optionally substituted heteroaryl; provided that a compound wherein Y and/or A1 is optionally substituted indol-3-yl is excluded, a tautomer, a prodrug, a pharmaceutically acceptable salt or a hydrate thereof has an inhibitory activity against an integrase.
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