Invention Grant
US06482835B2 PROCESSES FOR PRODUCING 7-ISOINDOLINE-QUINOLONECARBOXYLIC ACID DERIVATIVE AND ITS INTERMEDIATE, AS WELL AS SALT OF 7-ISOINDOLINE-QUINOLONECARBOXYLIC ACID DERIVATIVE, ITS HYDRATE AND COMPOSITION COMPRISING THE SAME AS ACTIVE INGREDIENT
有权
用于生产7-吗啉 - 喹啉酮羧酸衍生物及其中间体的方法，作为7-金刚烷 - 喹啉酮羧酸衍生物的盐，其水合物和包含其的组合物作为活性成分
- Patent Title: PROCESSES FOR PRODUCING 7-ISOINDOLINE-QUINOLONECARBOXYLIC ACID DERIVATIVE AND ITS INTERMEDIATE, AS WELL AS SALT OF 7-ISOINDOLINE-QUINOLONECARBOXYLIC ACID DERIVATIVE, ITS HYDRATE AND COMPOSITION COMPRISING THE SAME AS ACTIVE INGREDIENT
- Patent Title (中): 用于生产7-吗啉 - 喹啉酮羧酸衍生物及其中间体的方法，作为7-金刚烷 - 喹啉酮羧酸衍生物的盐，其水合物和包含其的组合物作为活性成分
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Application No.: US09961364Application Date: 2001-09-25
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Publication No.: US06482835B2Publication Date: 2002-11-19
- Inventor: Minoru Yamada , Shoichi Hamamoto , Kazuya Hayashi , Kazuko Takaoka , Hiroko Matsukura , Minako Yotsuji , Kenji Yonezawa , Katsuji Ojima , Tamotsu Takamatsu , Kyoko Taya , Hirohiko Yamamoto , Taro Kiyoto , Hironori Kotsubo
- Applicant: Minoru Yamada , Shoichi Hamamoto , Kazuya Hayashi , Kazuko Takaoka , Hiroko Matsukura , Minako Yotsuji , Kenji Yonezawa , Katsuji Ojima , Tamotsu Takamatsu , Kyoko Taya , Hirohiko Yamamoto , Taro Kiyoto , Hironori Kotsubo
- Priority: JP9-311376 19971027; JP10-092807 19980320; JP10-140586 19980507; JP10-244828 19980831; JP10-253656 19980908
- Main IPC: A61K3147
- IPC: A61K3147
Abstract:
Processes for producing a 7-isoindoline-quinolonecarboxylic acid derivative represented by the general formula [1] which is useful as an antibacterial agent, and an intermediate thereof: comprising reacting, in the presence of metallic palladium, an isoindoline-5-boronic acid, or of a 5-halogenoisoindoline, in the presence of a palladium catalyst, with a dialkoxyborane or an alkoxydiborane.
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