发明授权
US06376683B1 Process for the preparation of (4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydropyran-2-one
失效
（4R，6S）-4-羟基-6-羟甲基 - 四氢吡喃-2-酮的制备方法
- 专利标题： Process for the preparation of (4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydropyran-2-one
- 专利标题（中）： （4R，6S）-4-羟基-6-羟甲基 - 四氢吡喃-2-酮的制备方法
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申请号： US09872849申请日： 2001-06-01
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公开(公告)号： US06376683B1公开(公告)日： 2002-04-23
- 发明人: Pradeep Kumar , Rodney Agustinho Fernandes
- 申请人： Pradeep Kumar , Rodney Agustinho Fernandes
- 主分类号： C07D30930
- IPC分类号： C07D30930
摘要：
The present invention relates to an improved, efficient and enantio-selective process for the synthesis of (4R, 6S)-4-hydroxy-6-hydroxymethyl tetrahydropyran-2-one, employing the Sharpless asymmetric dihydroxylation and regiospecific nucleophilic hydride opening of the cyclic sulfite/sulfate as the key steps. The invention also resides in the intermediates used in the process.
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