Invention Grant
US06323210B2 Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
失效
抗增殖取代的5-硫代嘧啶酮和5-硒代嘧啶酮化合物
- Patent Title: Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
- Patent Title (中): 抗增殖取代的5-硫代嘧啶酮和5-硒代嘧啶酮化合物
-
Application No.: US09782284Application Date: 2001-02-14
-
Publication No.: US06323210B2Publication Date: 2001-11-27
- Inventor: Michael D. Varney , William H. Romines , Cynthia L. Palmer , Judith G. Deal
- Applicant: Michael D. Varney , William H. Romines , Cynthia L. Palmer , Judith G. Deal
- Main IPC: C07D23936
- IPC: C07D23936
Abstract:
Novel derivatives of 5-thia- and 5-selenopyrimidinone are sound to inhibit the enzyme glycinamide ribonucleotide formyl transferase (GARFT) and amino imidazole carboxamide ribonucleotide formyl transferase (AICARFT). Novel intermediates of these compounds are also disclosed. A novel method of preparing such compounds is also disclosed, as well as methods and compositions for employing the compounds as antiproliferative agents.
Public/Granted literature
- US20010018443A1 Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds Public/Granted day:2001-08-30
Information query
