发明授权
- 专利标题: Process for the production of indole derivatives
- 专利标题(中): 吲哚衍生物生产工艺
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申请号: US09381072申请日: 2000-03-24
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公开(公告)号: US06281357B1公开(公告)日: 2001-08-28
- 发明人: David Charles Waite
- 申请人: David Charles Waite
- 优先权: GB9714383 19970708
- 主分类号: C07D20914
- IPC分类号: C07D20914
摘要:
The invention provides a process for the production of a compound of formula I, which comprises reacting a compound of formula II with a compound of formula III, in the presence of a strong base and a palladium(0) catalyst, at an elevated temperature, in a solvent which does not adversely affect the reaction. Compounds of formula I may be further processed to compounds of formula V, which are useful in the treatment of inter alia migraine.
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