发明授权
- 专利标题： Indole derivatives as 5-HT receptor antagonist
- 专利标题（中）： 吲哚衍生物作为5-HT受体拮抗剂
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申请号： US09359606申请日： 1999-07-23
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公开(公告)号： US06235758B1公开(公告)日： 2001-05-22
- 发明人: Laramie Mary Gaster , Paul Adrian Wyman , Keith Raymond Mulholland , David Thomas Davies , David Malcolm Duckworth , Ian Thomson Forbes , Graham Elgin Jones
- 申请人： Laramie Mary Gaster , Paul Adrian Wyman , Keith Raymond Mulholland , David Thomas Davies , David Malcolm Duckworth , Ian Thomson Forbes , Graham Elgin Jones
- 优先权： GB9502052 19950202; GB9508327 19950425; GB9508967 19950503; GB9516845 19950817; GB9517542 19950826; GB9518574 19950912
- 主分类号： C07D40104
- IPC分类号： C07D40104
摘要：
A compound of formula (I) or a salt thereof: wherein: P1 is pyridiyl; P2 is phenyl; A is a bond or a chain of 1 to 5 atoms optionally substituted by C1-6 alkyl; R1 and R2 groups are each independently hydrogen, C1-6alkyl optionally substituted by NR12R13, C2-6alkenyl, C2-6alkynyl, cyano, halogen, CF3, NR12R13, CHO, OCF3, COR14, CH2OR14 or OR14 where R12, R13 and R14 are independently hydrogen or C1-6alkyl; n and m are independently 0, 1 or 2; R3 is hydrogen or C1-6 alkyl; R4 is a group of formula (i): in which: R6 and R7 are independently hydrogen, C1-6 alkyl optionally substituted by one or more fluorine atoms, C1-6alkylthio, C1-6alkoxy or halogen.
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