发明授权
- 专利标题： Water soluble analogues of 20(S)-camptothecin
- 专利标题（中）： 20（S） - 喜树碱的水溶性类似物
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申请号： US08771391申请日： 1996-12-19
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公开(公告)号： US06177439B1公开(公告)日： 2001-01-23
- 发明人: Subrahmanyam Duvvuri , Venkateswarlu Akella , Sharma Manohara Vedula , Sastry V. R. S. Thungathurthi , Vamsee Krishna Chintakunta , Shobha Madabhushi
- 申请人： Subrahmanyam Duvvuri , Venkateswarlu Akella , Sharma Manohara Vedula , Sastry V. R. S. Thungathurthi , Vamsee Krishna Chintakunta , Shobha Madabhushi
- 主分类号： A61K34745
- IPC分类号： A61K34745
摘要：
Novel water soluble C-ring analogues of 20(S)-camptothecin having the general formula 1, All the compounds of the formula 1 are prepared from the compounds of the general formula 2 having 20(S)-chiral carbon where R1 to R5 have the meaning given above. The compounds of the formula 1 possess potent anti-cancer and anti-viral properties. The invention also provides an alternate process for the preparation of known C-5 substituted compounds of the formula 1,
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