Invention Grant
US6147215A Process for producing 1-chlorocarbonyl-4-piperidinopiperidine or
hydrochloride thereof
有权
1-氯羰基-4-哌啶哌啶或其盐酸盐的制备方法
- Patent Title: Process for producing 1-chlorocarbonyl-4-piperidinopiperidine or hydrochloride thereof
- Patent Title (中): 1-氯羰基-4-哌啶哌啶或其盐酸盐的制备方法
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Application No.: US402470Application Date: 1999-10-12
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Publication No.: US6147215APublication Date: 2000-11-14
- Inventor: Hiroshi Hirota
- Applicant: Hiroshi Hirota
- Applicant Address: JPX Tokyo
- Assignee: Kabushiki Kaisha Yakult Honsha
- Current Assignee: Kabushiki Kaisha Yakult Honsha
- Current Assignee Address: JPX Tokyo
- Priority: JPX9-093723 19970411
- Main IPC: C07D211/58
- IPC: C07D211/58 ; C07D211/60
Abstract:
The present invention provides a highly safe and easily operable process for producing 1-chlorocarbonyl-4-piperidinopiperidine or hydrochloride thereof in a high yield. Described specifically, the present invention relates to a process for producing 1-clorocarbonyl-4-piperidinopiperidine or hydrochloride thereof, which comprises reacting 4-piperidinopiperidine with a trialkylsilyl halide to obtain a 4-piperidinopiperidinyl trialkylsilyl, reacting it with a carbon dioxide gas to obtain a 4-piperidinopiperidinyl trialkylsilyl carbamate derivative, reacting the derivative with thionyl chloride or the like to obtain 1-chlorocarbonyl-4-piperidinopiperidine hydrochloride and optionally treating it with a strong base.
Public/Granted literature
- US5710883A Hypertext document transport mechanism for firewall-compatible distributed world-wide web publishing Public/Granted day:1998-01-20
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