发明授权
- 专利标题： Quinoline and quinazoline derivatives inhibiting platelet-derived growth factor receptor autophosphorylation and pharmaceutical compositions containing the same
- 专利标题（中）： 喹啉和喹唑啉衍生物抑制血小板衍生生长因子受体自磷酸化和含有它们的药物组合物
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申请号： US68660申请日： 1998-05-06
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公开(公告)号： US6143764A公开(公告)日： 2000-11-07
- 发明人: Kazuo Kubo , Shinichi Ohyama , Toshiyuki Shimizu , Tsuyoshi Nishitoba , Shinichiro Kato , Hideko Murooka , Yoshiko Kobayashi
- 申请人： Kazuo Kubo , Shinichi Ohyama , Toshiyuki Shimizu , Tsuyoshi Nishitoba , Shinichiro Kato , Hideko Murooka , Yoshiko Kobayashi
- 申请人地址： JPX Tokyo-to
- 专利权人： Kirin Beer Kabushiki Kaisha
- 当前专利权人： Kirin Beer Kabushiki Kaisha
- 当前专利权人地址： JPX Tokyo-to
- 优先权： JPX7-313555 19951107; JPX8-62121 19960223
- 主分类号： C07D215/20
- IPC分类号： C07D215/20 ; C07D215/22 ; C07D215/233 ; C07D215/36 ; C07D239/88 ; C07D401/12 ; C07D405/10 ; C07D405/12 ; C07D409/12 ; C07D491/056 ; A61K31/47 ; A61K31/535 ; C07D215/16 ; C07D413/00
摘要：
The present invention relates to novel quinoline derivatives and quinazoline derivatives represented by the following formula (I): ##STR1## [wherein R.sub.1 and R.sub.2 are each independently H or C.sub.1 -C.sub.4 -alkyl, or R.sub.1 and R.sub.2 together form C.sub.1 -C.sub.3 -alkylene, X is O, S or CH.sub.2, W is CH or N, and Q is a substituted aryl group or substituted heteroaryl group] and their pharmaceutically acceptable salts, having platelet-derived growth factor receptor autophosphorylation inhibitory activity, to pharmaceutical compositions containing these compounds, and to methods for the treatment of diseases associated with abnormal cell growth such as tumors.
公开/授权文献
- USD394953S Shipping container 公开/授权日：1998-06-09
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