Invention Grant
US5994342A 3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives
useful as antitumor agents
失效
可用作抗肿瘤剂的3-（取代的甲基）-4-氧杂-1-氮杂双环[3.2.0]庚-7-酮衍生物
- Patent Title: 3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives useful as antitumor agents
- Patent Title (中): 可用作抗肿瘤剂的3-（取代的甲基）-4-氧杂-1-氮杂双环[3.2.0]庚-7-酮衍生物
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Application No.: US513802Application Date: 1997-04-04
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Publication No.: US5994342APublication Date: 1999-11-30
- Inventor: Rajeshwar Singh , Tomohiro Yamashita , Charles Fiakpui , George Thomas , Chan Ha , Hiroshi Matsumoto , Toshio Otani , Shinji Oie , Ronald Micetich
- Applicant: Rajeshwar Singh , Tomohiro Yamashita , Charles Fiakpui , George Thomas , Chan Ha , Hiroshi Matsumoto , Toshio Otani , Shinji Oie , Ronald Micetich
- Applicant Address: JPX Tokyo CAX Alberta
- Assignee: Taiho Pharmaceutical Co., Ltd.,Synphar Laboratories Inc.
- Current Assignee: Taiho Pharmaceutical Co., Ltd.,Synphar Laboratories Inc.
- Current Assignee Address: JPX Tokyo CAX Alberta
- Priority: GBX9400220 19940107
- Main IPC: A61K31/42
- IPC: A61K31/42 ; A61P35/00 ; C07D503/00
Abstract:
The present invention is based on the discovery that certain 3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives of formula I or a pharmaceutically acceptable salt thereof are useful as antitumor agents against sensitive and resistant tumor cells. ##STR1## Wherein X is NH or O, and R is defined in the specification.
Public/Granted literature
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