发明授权
- 专利标题: Process for the preparation of 5-hydroxymethylthiazoles
- 专利标题(中): 5-羟甲基噻唑的制备方法
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申请号: US921399申请日: 1997-08-29
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公开(公告)号: US5959118A公开(公告)日: 1999-09-28
- 发明人: Michael S. Allen
- 申请人: Michael S. Allen
- 申请人地址: IL Abbott Park
- 专利权人: Abbott Laboratories
- 当前专利权人: Abbott Laboratories
- 当前专利权人地址: IL Abbott Park
- 主分类号: C07D277/20
- IPC分类号: C07D277/20 ; C07D277/22 ; C07D277/24 ; C07D277/32
摘要:
The present invention discloses a process for the preparation of a hydroxymethylthiazole compound having formula 3: The process of the invention comprises reacting a halomethyl thiazole having the formula: ##STR1## with water, at an elevated temperature. Optionally, the reaction can be carried out in the presence of a base, such as sodium carbonate, which can react with any acid formed. In the process of the invention, X is a halogen atom; and R.sup.6 is selected from the group consisting of hydrogen, and halogen atoms. The invention also contemplates the preparation of acid addition salts of the hydroxymethylthiazole, compound 3.
公开/授权文献
- US5367319A Security protection for important documents and papers 公开/授权日:1994-11-22
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