发明授权
US5935964A 1,2,4-triazolo�1,5-c! pyrimidine heterocyclic analogues having
antagonistic activity on adenosine A.sub.2a receptor
失效
对腺苷A2a受体具有拮抗作用的1,2,4-三唑并[1,5-c]嘧啶杂环类似物
- 专利标题： 1,2,4-triazolo�1,5-c! pyrimidine heterocyclic analogues having antagonistic activity on adenosine A.sub.2a receptor
- 专利标题（中）： 对腺苷A2a受体具有拮抗作用的1,2,4-三唑并[1,5-c]嘧啶杂环类似物
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申请号： US66申请日： 1998-01-23
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公开(公告)号： US5935964A公开(公告)日： 1999-08-10
- 发明人: Pier Giovanni Baraldi , Barbara Cacciari , Monica Valeria Angela Viziano , Silvio Dionisotti , Ennio Ongini
- 申请人： Pier Giovanni Baraldi , Barbara Cacciari , Monica Valeria Angela Viziano , Silvio Dionisotti , Ennio Ongini
- 申请人地址： NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： NJ Kenilworth
- 优先权： ITXMI95A0167 19950728
- 主分类号： C07D487/14
- IPC分类号： C07D487/14 ; A61K31/505
摘要：
Disclosed are adenosine A.sub.2a receptor antagonists of the formula ##STR1## wherein A is pyrazole, imidazole or triazole ring; R is ##STR2## R.sub.1 and R.sub.2 are independently H, OH, halogen, alkoxy, alkyl, nitro, amino, CN, haloalkyl, haloalkoxy, carboxy or carboxamido; or the OH group together with one of R.sub.1 or R.sub.2, or R.sub.1 and R.sub.2 together, form a methylenedioxy group;and n is 0-4;said compounds are useful in the treatment of cardiovascular, central nervous system, and respiratory diseases.
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