Invention Grant
US5892008A Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy
erythromycin derivatives
失效
使用9-羟基红霉素衍生物制备6-O-甲基红霉素a的方法
- Patent Title: Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
- Patent Title (中): 使用9-羟基红霉素衍生物制备6-O-甲基红霉素a的方法
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Application No.: US991648Application Date: 1997-12-16
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Publication No.: US5892008APublication Date: 1999-04-06
- Inventor: Yi-Yin Ku , David A. Riley , Elaine C. Lee , Jien-Heh Tien
- Applicant: Yi-Yin Ku , David A. Riley , Elaine C. Lee , Jien-Heh Tien
- Applicant Address: IL Abbott Park
- Assignee: Abbott Laboratories
- Current Assignee: Abbott Laboratories
- Current Assignee Address: IL Abbott Park
- Main IPC: C07H17/08
- IPC: C07H17/08 ; C07H1/00
Abstract:
The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4"-hydroxyl groups of erythromycin A, selectively methylating the 6-position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A.
Public/Granted literature
- US5271289A Non-involute gear Public/Granted day:1993-12-21
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