The several screen frames of a multistation screen printing machine, such as a carousel screen printer, having multiple work supports movable to the printer stations in succession to effect successive printing of screen images on work pieces fixed to the supports are precisely registered with the work supports by providing each frame with registration means precisely located relative to the screen image on the frame, providing a selected work support with registration means precisely located relative to the printing position of a work piece on the selected support, effecting movement of the selected work support to the print stations in succession, adjusting the corresponding screen frame to directly align its registration means with the registration means on the selected work support, and securing the frame in fixed position.