Invention Grant
- Patent Title: Process for the preparatin of .beta.-lactam compounds
- Patent Title (中): β-内酰胺化合物的制备方法
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Application No.: US758433Application Date: 1991-08-30
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Publication No.: US5750684APublication Date: 1998-05-12
- Inventor: Herve Geerlandt , Claudine Grand' Henry
- Applicant: Herve Geerlandt , Claudine Grand' Henry
- Applicant Address: GB2 Middlesex
- Assignee: Beecham Group plc.
- Current Assignee: Beecham Group plc.
- Current Assignee Address: GB2 Middlesex
- Priority: GBX8235568 19821214
- Main IPC: C07D463/00
- IPC: C07D463/00 ; C07D499/00 ; C07D499/04 ; C07D499/21 ; C07D499/72 ; C07D501/04 ; C07D501/57 ; C07D505/00
Abstract:
The present invention provides a process for the substitution of an acylamino .beta.-lactam compound at the carbon atom carrying the acylamino group, which process comprises reacting the .beta.-lactam compound with an halogenating agent and a nucleophilic reagent; characterized in that the acylamino group has an acidic group on the carbon atom adjacent the carbonyl group. In particular the process of this invention comprises reacting a .beta.-lactam of partial structure (I): ##STR1## where X represents an acidic group; with an halogenating agent and a nucleophilic reagent.
Public/Granted literature
- US5781591A Digital method for detecting pulses of short duration and arrangement for implementing the method Public/Granted day:1998-07-14
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