- 专利标题： Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers
-
申请号： US463686申请日： 1995-06-05
-
公开(公告)号： US5741661A公开(公告)日： 1998-04-21
- 发明人: Stanley M. Goldin , Subbarao Katragadda , Lain-Yen Hu , N. Laxma Reddy , James B. Fischer , Andrew Gannett Knapp , Lee David Margolin
- 申请人： Stanley M. Goldin , Subbarao Katragadda , Lain-Yen Hu , N. Laxma Reddy , James B. Fischer , Andrew Gannett Knapp , Lee David Margolin
- 申请人地址： MA Cambridge
- 专利权人： Cambridge NeuroScience, Inc.
- 当前专利权人： Cambridge NeuroScience, Inc.
- 当前专利权人地址： MA Cambridge
- 主分类号： A61K31/155
- IPC分类号： A61K31/155 ; A61K31/37 ; A61K31/4453 ; C12Q1/02 ; A23J3/00 ; A01N37/52
摘要：
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.
公开/授权文献
- US3941788A Benzimidazole derivatives 公开/授权日：1976-03-02
信息查询
