Invention Grant
- Patent Title: Photo-induced DNA-cleaving agents
- Patent Title (中): 光诱导的DNA切割剂
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Application No.: US581314Application Date: 1995-12-29
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Publication No.: US5734032APublication Date: 1998-03-31
- Inventor: Jih Ru Hwu , Shwu-Chen Tsay , Buh-Luen Chen , Himatkumar V. Patel , Wan-Lin Chen , Chun Chieh Lin , Ching-Tai Chou
- Applicant: Jih Ru Hwu , Shwu-Chen Tsay , Buh-Luen Chen , Himatkumar V. Patel , Wan-Lin Chen , Chun Chieh Lin , Ching-Tai Chou
- Applicant Address: TWX Taipei
- Assignee: National Science Council
- Current Assignee: National Science Council
- Current Assignee Address: TWX Taipei
- Main IPC: C07H21/00
- IPC: C07H21/00 ; C12N15/10 ; C12Q1/68 ; C01B21/14
Abstract:
The present invention discloses a photo-induced DNA-cleaving agent composition comprises N-aryl-N-(alkyl or arylalkyl)hydroxylamine having the following formula: ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl, phenyl, C.sub.1 -C.sub.6 alkoxy, phenoxy, C.sub.1 -C.sub.6 alkoxycarbonyl, halogen or halo(C.sub.1 -C.sub.6 alkyl)wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkoxycarbonyl, halogen or halo(C.sub.1 -C.sub.6 alkyl); R.sub.2 is hydrogen; R.sub.3 is hydrogen or phenyl; R.sub.4 is hydrogen, phenyl, hydroxylphenyl, methoxyphenyl, dimethoxyphenyl, dimethylaminophenyl or naphthyl. The present N-aryl-N-(alkyl or arylalkyl)hydroxylamine is stable in dark, but it can react with O.sub.2 to form HO.multidot. radicals under irradiation of UV light for a period of 2-3 hours. The HO.multidot. radicals then react with DNA to accomplish cleavage of DNA.
Public/Granted literature
- US5134831A Method of improving the energy efficiency of a building Public/Granted day:1992-08-04
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