发明授权
US5668159A 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists
失效
1,3,4-噻二唑和1,3,4-恶二唑作为IIb / IIIa拮抗剂
- 专利标题： 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists
- 专利标题（中）： 1,3,4-噻二唑和1,3,4-恶二唑作为IIb / IIIa拮抗剂
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申请号： US643438申请日： 1996-05-08
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公开(公告)号： US5668159A公开(公告)日： 1997-09-16
- 发明人: Fuqiang Jin , Pasquale Nicholas Confalone
- 申请人： Fuqiang Jin , Pasquale Nicholas Confalone
- 申请人地址： DE Wilmington
- 专利权人： The DuPont Merck Pharmaceutical Company
- 当前专利权人： The DuPont Merck Pharmaceutical Company
- 当前专利权人地址： DE Wilmington
- 主分类号： C07D271/10
- IPC分类号： C07D271/10 ; C07D271/113 ; C07D285/12 ; C07D285/125 ; C07D413/04 ; C07D413/12 ; C07D413/14 ; C07D417/04 ; C07D417/12 ; C07D417/14 ; A61K31/41
摘要：
##STR1## This invention relates to improved isoxazoline compounds including, but not limited to 1,3,4-thiadiazoles and 1,3,4-oxadiazoles of the formula which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
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