发明授权
- 专利标题: Selective inhibitors of biogenic amine transporters
- 专利标题(中): 生物胺转运蛋白的选择性抑制剂
-
申请号: US203222申请日: 1994-02-28
-
公开(公告)号: US5574060A公开(公告)日: 1996-11-12
- 发明人: Richard Rothman , Frank J. Carroll , Bruce Blough , Samuel W. Mascarella
- 申请人: Richard Rothman , Frank J. Carroll , Bruce Blough , Samuel W. Mascarella
- 申请人地址: DC Washington MD Bethesda NC Research Triangle Park
- 专利权人: The United States of America as represented by the Department of Health and Human Services,Office of Technology Transfer,Research Triangle Institue
- 当前专利权人: The United States of America as represented by the Department of Health and Human Services,Office of Technology Transfer,Research Triangle Institue
- 当前专利权人地址: DC Washington MD Bethesda NC Research Triangle Park
- 主分类号: C07D487/18
- IPC分类号: C07D487/18 ; A61K31/40 ; A61K31/403 ; A61K31/435 ; A61P25/00 ; A61P25/24 ; A61P25/26 ; A61P43/00 ; C07D209/58 ; C07D209/70 ; C07D451/00 ; C07D471/08 ; A61K31/47 ; C07D403/06
摘要:
The present invention provides a compound having the structure: ##STR1## wherein X, Y, and Z are independently H, Cl, Br, F, OCH.sub.3, I, or an alkyl group having 1 to 6 carbon atoms; and R is ##STR2## wherein n is 0 to 6, X' and Y' are independently H, Cl, F, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7, C.sub.4 H.sub.9, OCH.sub.3, OH, CF.sub.3, OCF.sub.3, NO.sub.2, NH.sub.2, N(CH.sub.3).sub.2, NHCOCH.sub.3, NCS, NHCOCH.sub.2 Br, or N.sub.3, and (CH.sub.2).sub.n, if present, may be substituted with OH, OCH.sub.3, or an alkyl or alkenyl group having 1 to 3 carbon atoms. The present invention also provides a pharmaceutical composition comprising the compound above and a pharmaceutically acceptable carrier. The present invention further provides a method for treating a disease characterized by a dopamine deficiency which comprises administering to a subject in need of such treatment an amount of the pharmaceutical composition above effective to treat the disease.
公开/授权文献
- US6071130A Surface mounted contact block 公开/授权日:2000-06-06
信息查询