A universal pump coupling system that allows various style submersible pumps to be mounted to a pump mounting frame assembly to be used interchangeably within a single pump station system. The universal pump coupling system comprises a submersible pump holding device and universal guide rail assembly for use in both submersible and converted dry pit pump stations that allow numerous brands of pumps to be utilized in a single interchangeable system. The universal pump coupling system is particularly suitable for conversion of wet well/dry well pump stations to a single wet well pump station.